Jardiance and Kidney Stones: What You Need to Know
Published on December 28, 2024
Key Takeaway
While Jardiance is not directly associated with kidney stone formation, it may affect kidney function and fluid balance, requiring careful monitoring in patients prone to kidney stones.
Introduction
Jardiance (empagliflozin) is a widely prescribed medication for type 2 diabetes and heart failure. As with any medication, it's crucial to understand its potential effects on various aspects of health, including kidney function. In this article, we'll explore the relationship between Jardiance and kidney stones, providing you with essential information to manage your health effectively.
Understanding Jardiance and Its Effects on the Kidneys
Jardiance belongs to a class of drugs called SGLT2 inhibitors. It works by helping the kidneys remove excess glucose from the body through urine. While this mechanism is beneficial for blood sugar control, it can have implications for kidney function and fluid balance.
According to Healthline, Jardiance can affect kidney function in several ways:
- It may reduce the total amount of fluid in your body's blood vessels
- It can make your kidneys work less effectively, especially if you already have kidney damage
- It may increase the risk of dehydration
Jardiance and Kidney Stones: Is There a Direct Link?
While Jardiance is not directly associated with an increased risk of kidney stones, its effects on fluid balance and kidney function could potentially influence stone formation in susceptible individuals. Drugs.com reports that Jardiance is not recommended for patients with severe kidney disease or those on dialysis, indicating its significant impact on kidney function.

Factors That May Increase Kidney Stone Risk While Taking Jardiance
Several factors can contribute to an increased risk of kidney stones in patients taking Jardiance:
- Dehydration: Jardiance increases urination, which can lead to dehydration if fluid intake is not adequate.
- Existing kidney problems: Patients with a history of kidney issues may be more susceptible to complications.
- Diet: A diet high in oxalates or low in citrate can increase the risk of stone formation.
- Metabolic factors: Conditions like gout or high uric acid levels can contribute to stone formation.
Preventive Measures and Management
To minimize the risk of kidney stones while taking Jardiance, consider the following strategies:
- Stay well-hydrated: Drink plenty of water throughout the day to compensate for increased urination.
- Monitor kidney function: Regular check-ups and blood tests can help track your kidney health.
- Follow a balanced diet: Incorporate foods rich in magnesium and citrate, which may help prevent stone formation.
- Be aware of symptoms: Know the signs of kidney stones, such as back pain or blood in urine.
A study published in PubMed suggests that potassium-magnesium citrate supplementation may help reduce the risk of kidney stone formation in certain situations. However, always consult with your healthcare provider before starting any new supplement regimen.

When to Consult Your Doctor
If you're taking Jardiance and experience any of the following symptoms, contact your healthcare provider immediately:
- Severe back or abdominal pain
- Blood in urine
- Frequent urinary tract infections
- Difficulty urinating
- Signs of dehydration (extreme thirst, dizziness, dark urine)
Conclusion
While Jardiance is an effective medication for managing diabetes and heart failure, it's essential to be aware of its potential effects on kidney function and the indirect risk of kidney stones. By staying informed, maintaining good hydration, following a balanced diet, and regularly monitoring your health with your healthcare provider, you can minimize risks and maximize the benefits of your treatment. Remember, your health is a partnership between you and your medical team – don't hesitate to discuss any concerns or questions about Jardiance and your kidney health.