Lipomas vs Cysts: Key Differences and How to Tell Them Apart
Published on January 7, 2025
Key Takeaway
While lipomas and cysts can appear similar, they have distinct characteristics in terms of composition, texture, and imaging features that help differentiate them for proper diagnosis and treatment.
Introduction
Finding a lump under your skin can be alarming, but more often than not, it's harmless. Two of the most common types of benign soft tissue lumps are lipomas and cysts. While they may look similar at first glance, these growths have distinct characteristics that set them apart. Understanding these differences is crucial for proper diagnosis and treatment.
What is a Lipoma?
A lipoma is a benign tumor composed of mature fat cells (adipocytes). According to a 2022 study, lipomas are the most common type of soft tissue tumor, with 95% of them being benign. They typically appear as soft, doughy masses just under the skin and can occur anywhere on the body.
Key Characteristics of Lipomas:
- Soft and rubbery to the touch
- Usually painless
- Mobile when pressed with fingers
- Typically slow-growing
- Most common in adults between 40 and 60 years old

What is a Cyst?
A cyst, on the other hand, is a sac-like pocket of tissue that can be filled with fluid, air, or other material. As explained by Healthline, cysts can appear in your skin, tissue, organs, and bones.
Key Characteristics of Cysts:
- Often have a more defined shape than lipomas
- Can be firm or soft, depending on location and contents
- May be painful, especially if infected
- Can grow larger than lipomas
- May cause redness and irritation of the skin

Differentiating Lipomas from Cysts
While lipomas and cysts can be similar in appearance, there are several key factors that help distinguish them:
1. Texture and Mobility
Lipomas typically feel soft and rubbery and can be moved around easily under the skin. Cysts, however, are often firmer and less mobile. A study by Healthline notes that cysts have a more defined shape and don't move like lipomas when pressed.
2. Size and Growth
Lipomas generally don't grow larger than 3 centimeters in length, while cysts can potentially grow much larger. A 2021 case study reported a cyst that had been gradually increasing in size for two years.
3. Pain and Discomfort
Lipomas are usually painless unless they press on nearby nerves. Cysts, especially if infected, can be painful and may cause skin irritation.
4. Imaging Characteristics
On imaging studies like MRI or CT scans, lipomas and cysts have distinct appearances. A study by Dooms et al. found that lipomas show a fatty component readily demonstrable on both MR and CT, while cysts appear as fluid-filled structures.

Diagnosis and Treatment
Accurate diagnosis of lipomas and cysts is crucial for proper treatment. While many can be diagnosed through physical examination, imaging studies may be necessary in some cases.
Diagnostic Methods:
- Physical examination
- Ultrasound
- MRI or CT scan
- Biopsy (in rare cases)
Treatment Options:
Treatment depends on the size, location, and symptoms of the growth. A 2015 study by Copeland-Halperin et al. found that for lipomas, a combination of liposuction and limited surgical excision can provide satisfactory aesthetic results with low recurrence rates.
For cysts, treatment options may include:
- Drainage (for infected cysts)
- Steroid injections
- Surgical removal
Conclusion
While lipomas and cysts may appear similar at first glance, they have distinct characteristics that set them apart. Understanding these differences can help patients and healthcare providers make informed decisions about diagnosis and treatment. If you discover a lump or growth on your body, it's always best to consult with a healthcare professional for proper evaluation and care.